Episode 11: The Unique Nature of This Virus: HHV-6 Artwork

Addressing D.R.E.S.S. Podcast

Brought to you by the D.R.E.S.S. Syndrome Foundation and hosted by Connie Stevens. An educational podcast on the severe adverse drug reaction known as D.R.E.S.S. Syndrome. Drug Reaction with Eosinophilia and Systemic Symptoms is often under-recognized and misdiagnosed. We talk with patients who have been touched by this horrific condition and experts who are working to prevent it, treat it, and create better awareness.

All Episodes

Addressing D.R.E.S.S. Podcast

Episode 11: The Unique Nature of This Virus: HHV-6

November 30, 2020 • Dr. Bhupesh Prusty, Dr. Hideo Asada • Season 1 • Episode 11

German virologist, Dr. Bhupesh Prusty, discusses his research on the human herpes virus, HHV-6, and its important role in many medical conditions including DRESS syndrome.

We then hear from Japanese dermatologist and DRESS expert, Dr. Hideo Asada, about the long-term complications associated with HHV-6 and DRESS.

Interview: Dr. Bhupesh Prusty (Molecular virologist University of Wuerberg, Germany), Dr. Hideo Asada (Professor, Researcher at the Department of Dermatology Nara Medical University in Japan), June, 2019 in Quebec, Canada

PUBLICATIONS/RESOURCES:

Dr. Bhupesh Prusty:

Chronic persistent HHV‐6B infection after sulfasalazine‐induced DRESS with demonstration of HHV‐6 encoded small noncoding RNAs (sncRNAs) in Crohn’s‐like colitis: Case report: https://onlinelibrary.wiley.com/doi/full/10.1002/ccr3.3680?af=R

HHV-6 encoded small non-coding RNAs deﬁne an intermediate and early stage in viral reactivation: https://www.nature.com/articles/s41525-018-0064-5

Additional Publications/Researchgate: https://www.researchgate.net/profile/Bhupesh-Prusty

Dr. Hideo Asada:

Dynamics of chemokines in severe drug hypersensitivity: https://ctajournal.biomedcentral.com/articles/10.1186/2045-7022-4-S3-P29

Parallel changes in serum thymus and activation‐regulated chemokine levels in response to flare‐ups in drug‐induced hypersensitivity syndrome: https://onlinelibrary.wiley.com/doi/pdf/10.1111/1346-8138.15548

Preferential expression of CD134, an HHV-6 cellular receptor, on CD4T cells in drug-induced hypersensitivity syndrome (DIHS)/drug reaction with eosinophilia and systemic symptoms (DRESS): https://hhv-6foundation.org/transplant-complications/cd134-upregulation-may-explain-why-hhv-6-reactivates-preferentially-in-dress

Facial pustules due to drug-induced hypersensitivity syndrome/drug reaction with eosinophilia and systemic symptoms may histopathologically mimic eosinophilic pustular folliculitis: A case report: https://pubmed.ncbi.nlm.nih.gov/30666704/

Sequelae in 145 patients with drug-induced hypersensitivity syndrome/drug reaction with eosinophilia and systemic symptoms: survey conducted by the Asian Research Committee on Severe Cutaneous Adverse Reactions (ASCAR): https://pubmed.ncbi.nlm.nih.gov/25623158/

Drug-induced hypersensitivity syndrome/drug reaction with eosinophilia and systemic symptoms or non-drug-related erythroderma with a persistent human herpesvirus 6 infection: https://doi.org/10.1111/1346-8138.15145